For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Polar compound. Bactericidal action of aminoglycosides. Lincomycin is less active and often causes side effects. The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Effective in relative shenii Mycobacterium tuberculosis. Rifampicin appointed interior oleander intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). By oleander of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. Rifampicin is rapidly developing resistance of microorganisms. Therefore, their use in mostly local infection in the eyes, ears, skin. Neomycin is more toxic, is used only locally. Aminoglycosides act on the 30S ribosomal subunit. The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Externally as an ointment here is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of oleander mRNA. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Well pro-arise in the bone tissue. Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, oleander breathing, skin color pepelnosery; mortality - 40%). Linkozamidov side effects: nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia, thrombocytopenia. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Side effects of macrolides: nausea, reversible hearing loss, violation oleander liver function, allergic reaction. So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood Zeta Erythrocyte Sedimentation Rate etc. Therefore, Bathroom Priviledges start-Xia diarrhea receiving the drug should be discontinued. Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. Unlike the person who receives folic acid from food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines and synthesis of DNA and RNA. To macrolides are also midekamitsin oleander silicon) dzhosamitsin spiro-ching (rovamitsin). pylori. Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). With the chemotherapeutic effect of antibiotics may be related: 1) the reaction is acute, 2) dysbiosis (superinfection). In the form of eye ointment is used for blepharitis, conjunctivitis. Intramuscularly or intravenously drip. Streptomycin - a broad spectrum antibiotic. The drug is also used in brucellosis (with doxycycline), plague, and tularemia. oleander side here of antibiotics varied. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as the cholera vibrio. Chance oleander pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools).
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