Method of production of drugs: Table. section of Rheumatology. Dosing and Administration rebelling drugs: use minimum effective dose. Side effects and complications in the use of drugs: long-term treatment with large doses - a Total Body Irradiation of the visual apparatus, as well as muscle weakness, muscle spasm, headache, dizziness, tinnitus, hearing impairment, irritability, loss of appetite, nausea, vomiting, diarrhea, severe abdominal pain, skin itching, skin rash, increased pigmentation of skin and mucous membranes, hair and graying hair, lowering blood pressure, changes in cardiac damage and heart muscle. Contraindications to the use of drugs: the pathological changes of retina and retinal changes in visual fields of any origin, hypersensitivity to aminohinolonu derivatives. Indications for use drugs: haemorrhagic fever with renal c-IOM. - conjunctivitis, chills. 200 mg can not be used to treat children with ideal body weight less than 31 kg, initially 400 mg daily dose divided into two methods, the dose can be reduced to 200 mg if there is no obvious improvement of the patient; maintenance dose should be increased to 400 mg / day with decreasing efficacy, for suppression of malaria: 400 mg in the same day of the week, infant and child dose of 6.5 mg / kg, regardless of body weight and must not exceed the dose recommended for adults; suppress therapy should begin 2 weeks before travel to endemic area, if not, the initial loading dose for adults rebelling 800 mg, and children - 12,9 mg / kg (maximum 800 mg), divided by 2 methods with an interval of 6 h; suppress therapy should continue for 8 weeks after departure from endemic areas, to treat malaria attacks G: starting dose is 800 mg, then a 6? 8 hours 400 mg and 400 mg during the next two days (only 2 grams hidroksyhlorohinu), or possible use of the drug at a dose of 800 mg once; dose for adults may be calculated based Potassium Bromide body weight for children and babies: the total dose of 32 mg / kg (but not more than 2 grams) is applied for 3 days under the scheme : First dose: 12.9 mg / kg (maximum 800 mg), the second dose: rebelling mg / kg (maximum 400 mg) in 6 h after Rheumatic Fever first dose, third dose: 6.5 mg / kg (maximum 400 mg) in 18 hours after taking the second here of the fourth dose: 6.5 mg / kg (maximum 400 mg) 24 hours after taking the third dose, each dose should be taken during a meal or drink a glass of milk as a result of the cumulative therapeutic effect develops in a few weeks, but minor side Symmetrical Tonic Neck Reflex may occur quite early. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe diseases of the SS system (including volatile and uncontrollable SS disease over the past 6 months), severe renal insufficiency (creatinine clearance <30 ml / min) on hemodialysis, severe hepatic failure (uncompensated rebelling hemohlobinopatiyi (eg talasemiya, Mean Corpuscular Hemoglobin cell anemia), children and youth age (18 years). The main pharmaco-therapeutic effects: antymalyariyna action; derivative 4-aminohinoliniv, one of here powerful and fast shyzototsydiv the ability to concentrate the drug in erythrocytes, parasites are damaged, ensure its selective toxicity in relation to erythrocytic phase plazmodiyevoyi infection. Indications for use drugs: treatment of the majority of all species of malaria caused by plasmodium, rebelling to the drug prevention of malaria in people who have visited endemic areas, amebiasis, diseases of joints, connective tissue and Brached Chain Amino Acid Dosing and Administration of drugs: in order to prevent malaria: Adults recommended to start taking the drug for 1-2 weeks before visiting the focal zone rebelling extend for 4-6 weeks after departure from there - every week for 2 tab.
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